The International Tinnitus Journal

Correlation between brain cortex metabolic and perfusion functions in subjective idiopathic tinnitus

Author(s): Saeid Mahmoudian, Mohammad Farhadi, Saeid Gholami, Fariba Saddadi, Maryam Jalesi, Ali Reza Karimian, Maryam Darbeheshti, Sara Momtaz and Sara Fardin

OBJECTIVES: Subjective tinnitus has associated with abnormal brain metabolism and perfusion found in functional imaging studies by fluorodeoxyglucose (FDG) and technetium99m (TC99m). But there is no study evaluating the association of brain metabolism and perfusion abnormalities in a group of these subjects. The aim of this study was to investigate if there is any significant correlation between the brain perfusion and metabolism abnormalities in subjects with tinnitus.

MATERIALS AND METHODS: In this cross-sectional study, 52 patients were undergone TC99m-ECD single photon emission computerized tomography (SPECT) scan and F18-FDG positron emission tomography (PET). The results of PET and SPECT scanning were fused with MRI to accurate anatomical localization of abnormalities. The analysis was performed using Kendal's correlation, t-test and chi square.

RESULTS: Assessing these 52 tinnitus subjects (containing 42 males [76.4%]) showed that a significant correlation was found between the brain metabolic function and perfusion (p value 0.001).

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